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KMID : 0606920100180030321
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Biomolecules & Therapeutics
2010 Volume.18 No. 3 p.321 ~ p.328
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Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica
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Zheng Ming-Shan
Yang Ju-Hye
Son Jong-Keun
Li Ying
Li Xian
Chang Hyeun-Wook
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Abstract
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Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated against the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin D2 generation but also 5-lipoxygenase dependent leukotrien C4 generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited β-hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.
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KEYWORD
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Ulmus davidiana var. japonica, Bone marrow-derived mast cells, Cyclooxygenase-2, 5-Lipoxygenase, β-hexosaminidase, Anti-inflammatory activity
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